Selective fluorination of pyridine and its derivatives in the presence of high-oxidation-state transition metals

T. V. Gryaznova; V. V. Khrizanforova; K. V. Kholin; M. N. Khrizanforov; Yu. H. Budnikova

doi:10.1007/s11172-016-1513-x

Selective fluorination of pyridine and its derivatives in the presence of high-oxidation-state transition metals

Authors: Gryaznova T.V.¹, Khrizanforova V.V.¹, Kholin K.V.¹, Khrizanforov M.N.¹, Budnikova Y.H.¹
Affiliations:
1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Issue: Vol 65, No 7 (2016)
Pages: 1798-1804
Section: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/238582
DOI: https://doi.org/10.1007/s11172-016-1513-x
ID: 238582

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Abstract

The oxidative fluorination of pyridine and 4-ethylpyridine under chemical and electro-chemical conditions in the presence of transition metal (high-oxidation-state nickel, cobalt, and silver) salts was studied. The chemical fluorination affords 2-fluoropyridine in all cases, while the electrochemical fluorination results in 2-fluoroor 3-fluoropyridine depending on the catalyst used.