Email this article Antiproliferative activity of ruthenium and osmium clusters with phosphine ligands
- Authors: Nazarov A.A.1, Nosova Y.N.1, Mikhalev O.V.1, Kovaleva O.N.2, Dyson P.J.3, Milaeva E.R.1
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Affiliations:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- I. M. Sechenov First Moscow State Medical University
- Swiss Federal Institute of Technology in Lausanne
- Issue: Vol 65, No 2 (2016)
- Pages: 546-549
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/237279
- DOI: https://doi.org/10.1007/s11172-016-1335-x
- ID: 237279
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Abstract
New ruthenium and osmium carbonyl clusters with 1,3,5-triaza-7-phosphatricyclo-[3.3.1.13.7]decane and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane ligands were synthesized using Me3NO as an initiator. The data on antiproliferative activity of new compounds against ovarian carcinoma cell cultures A2780 (cisplatin-sensitive) and A2780cisR (cisplatin-resistant) are reported. The dependence of cytotoxicity on the number of phosphine ligands was demonstrated.
About the authors
A. A. Nazarov
Department of Chemistry, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: nazarov@med.chem.msu.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991
Yu. N. Nosova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: nazarov@med.chem.msu.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991
O. V. Mikhalev
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: nazarov@med.chem.msu.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991
O. N. Kovaleva
I. M. Sechenov First Moscow State Medical University
Email: nazarov@med.chem.msu.ru
Russian Federation, Build. 2, 8 ul. Trubetskaya, Moscow, 119991
P. J. Dyson
Swiss Federal Institute of Technology in Lausanne
Email: nazarov@med.chem.msu.ru
Switzerland, Lausanne
E. R. Milaeva
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: nazarov@med.chem.msu.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991
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