Synthesis and antioxidant properties of benzimidazole derivatives with isobornylphenol fragments
- Authors: Dvornikova I.A.1, Buravlev E.V.1, Fedorova I.V.1, Shevchenko O.G.2, Chukicheva I.Y.1, Kutchin A.V.1
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Affiliations:
- Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
- Institute of Biology of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
- Issue: Vol 68, No 5 (2019)
- Pages: 1000-1005
- Section: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243371
- DOI: https://doi.org/10.1007/s11172-019-2510-7
- ID: 243371
Cite item
Abstract
A series of new 2-substituted-1H-benzimidazoles was synthesized on the basis of 4-hydroxybenzaldehydes. Their antioxidant properties were evaluated in the in vitro models and compared with those of known analogs. The structural specifi c features of the molecules responsible for the high antioxidant activity were revealed. Among tested derivatives, 2-substituted 1H-benzimidazole containing a phenol fragment with isobornyl and tert-butyl groups was found to have the greatest ability to protect biomolecules and cells under conditions of acute oxidative stress.
About the authors
I. A. Dvornikova
Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: dvornikova-ia@chemi.komisc.ru
Russian Federation, 48 ul. Pervomaiskaya, Syktyvkar, 167000
E. V. Buravlev
Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: dvornikova-ia@chemi.komisc.ru
Russian Federation, 48 ul. Pervomaiskaya, Syktyvkar, 167000
I. V. Fedorova
Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: dvornikova-ia@chemi.komisc.ru
Russian Federation, 48 ul. Pervomaiskaya, Syktyvkar, 167000
O. G. Shevchenko
Institute of Biology of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: dvornikova-ia@chemi.komisc.ru
Russian Federation, 28 ul. Kommunisticheskaya, Syktyvkar, 167982
I. Yu. Chukicheva
Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: dvornikova-ia@chemi.komisc.ru
Russian Federation, 48 ul. Pervomaiskaya, Syktyvkar, 167000
A. V. Kutchin
Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: dvornikova-ia@chemi.komisc.ru
Russian Federation, 48 ul. Pervomaiskaya, Syktyvkar, 167000