Synthesis and antioxidant properties of benzimidazole derivatives with isobornylphenol fragments
- Авторлар: Dvornikova I.1, Buravlev E.1, Fedorova I.1, Shevchenko O.2, Chukicheva I.1, Kutchin A.1
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Мекемелер:
- Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
- Institute of Biology of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
- Шығарылым: Том 68, № 5 (2019)
- Беттер: 1000-1005
- Бөлім: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243371
- DOI: https://doi.org/10.1007/s11172-019-2510-7
- ID: 243371
Дәйексөз келтіру
Аннотация
A series of new 2-substituted-1H-benzimidazoles was synthesized on the basis of 4-hydroxybenzaldehydes. Their antioxidant properties were evaluated in the in vitro models and compared with those of known analogs. The structural specifi c features of the molecules responsible for the high antioxidant activity were revealed. Among tested derivatives, 2-substituted 1H-benzimidazole containing a phenol fragment with isobornyl and tert-butyl groups was found to have the greatest ability to protect biomolecules and cells under conditions of acute oxidative stress.
Авторлар туралы
I. Dvornikova
Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: dvornikova-ia@chemi.komisc.ru
Ресей, 48 ul. Pervomaiskaya, Syktyvkar, 167000
E. Buravlev
Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: dvornikova-ia@chemi.komisc.ru
Ресей, 48 ul. Pervomaiskaya, Syktyvkar, 167000
I. Fedorova
Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: dvornikova-ia@chemi.komisc.ru
Ресей, 48 ul. Pervomaiskaya, Syktyvkar, 167000
O. Shevchenko
Institute of Biology of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: dvornikova-ia@chemi.komisc.ru
Ресей, 28 ul. Kommunisticheskaya, Syktyvkar, 167982
I. Chukicheva
Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: dvornikova-ia@chemi.komisc.ru
Ресей, 48 ul. Pervomaiskaya, Syktyvkar, 167000
A. Kutchin
Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: dvornikova-ia@chemi.komisc.ru
Ресей, 48 ul. Pervomaiskaya, Syktyvkar, 167000