Email this article Bis(nitroxide) methanofullerene as SOD-mimetic in reactions with catecholamines
- Authors: Melnikova N.B.1, Solovyeva O.N.1, Muzykina V.M.1, Gubskaya V.P.2, Fazleeva G.M.2, Poddelsky A.I.3
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Affiliations:
- Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation
- A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
- G. A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences
- Issue: Vol 68, No 1 (2019)
- Pages: 149-157
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243291
- DOI: https://doi.org/10.1007/s11172-019-2430-6
- ID: 243291
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Abstract
The reactions of a SOD-mimetic, bis(nitroxide) methanofullerene, with dopamine and 6-hydroxydopamine and the properties of its adsorption and Langmuir mono- and transferred layers were studied by methods of UV spectroscopy and EPR. The used fullerene derivative oxidizes catecholamines to cyclic and noncyclic quinones, whereas in a medium of phytic acid their oxidation products can be reduced. The inhibition effect of nitroxide fullerene in a phytic acid medium on the autocatalytic process of dopamine oxidation to its neurotoxic metabolite can be used for both the biomimetic prediction of stability of catecholamines and therapy of neurodegenerative diseases.
About the authors
N. B. Melnikova
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: melnikovanb@gmail.com
Russian Federation, 10/1 pl. Minina i Pozharskogo, Nizhny Novgorod, 603005
O. N. Solovyeva
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation
Email: aip@iomc.ras.ru
Russian Federation, 10/1 pl. Minina i Pozharskogo, Nizhny Novgorod, 603005
V. M. Muzykina
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation
Email: aip@iomc.ras.ru
Russian Federation, 10/1 pl. Minina i Pozharskogo, Nizhny Novgorod, 603005
V. P. Gubskaya
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Author for correspondence.
Email: arbuzov@iopc.ru
Russian Federation, 8 ul. Arbuzova, Kazan, 420088
G. M. Fazleeva
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: aip@iomc.ras.ru
Russian Federation, 8 ul. Arbuzova, Kazan, 420088
A. I. Poddelsky
G. A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: aip@iomc.ras.ru
Russian Federation, 49 ul. Tropinina, Nizhny Novgorod, 603137
