电邮这篇文章 Bis(nitroxide) methanofullerene as SOD-mimetic in reactions with catecholamines
- 作者: Melnikova N.1, Solovyeva O.1, Muzykina V.1, Gubskaya V.2, Fazleeva G.2, Poddelsky A.3
-
隶属关系:
- Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation
- A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
- G. A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences
- 期: 卷 68, 编号 1 (2019)
- 页面: 149-157
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243291
- DOI: https://doi.org/10.1007/s11172-019-2430-6
- ID: 243291
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
订阅存取
详细
The reactions of a SOD-mimetic, bis(nitroxide) methanofullerene, with dopamine and 6-hydroxydopamine and the properties of its adsorption and Langmuir mono- and transferred layers were studied by methods of UV spectroscopy and EPR. The used fullerene derivative oxidizes catecholamines to cyclic and noncyclic quinones, whereas in a medium of phytic acid their oxidation products can be reduced. The inhibition effect of nitroxide fullerene in a phytic acid medium on the autocatalytic process of dopamine oxidation to its neurotoxic metabolite can be used for both the biomimetic prediction of stability of catecholamines and therapy of neurodegenerative diseases.
作者简介
N. Melnikova
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: melnikovanb@gmail.com
俄罗斯联邦, 10/1 pl. Minina i Pozharskogo, Nizhny Novgorod, 603005
O. Solovyeva
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation
Email: aip@iomc.ras.ru
俄罗斯联邦, 10/1 pl. Minina i Pozharskogo, Nizhny Novgorod, 603005
V. Muzykina
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation
Email: aip@iomc.ras.ru
俄罗斯联邦, 10/1 pl. Minina i Pozharskogo, Nizhny Novgorod, 603005
V. Gubskaya
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: arbuzov@iopc.ru
俄罗斯联邦, 8 ul. Arbuzova, Kazan, 420088
G. Fazleeva
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: aip@iomc.ras.ru
俄罗斯联邦, 8 ul. Arbuzova, Kazan, 420088
A. Poddelsky
G. A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: aip@iomc.ras.ru
俄罗斯联邦, 49 ul. Tropinina, Nizhny Novgorod, 603137
