Email this article Antiulcerogenic activity of borneol derivatives
- Authors: Borisova M.S.1, Yarovaya O.I.1,2, Semenova M.D.1, Tolstikova T.G.1,2, Salakhutdinov N.F.1,2
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Affiliations:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Novosibirsk State University
- Issue: Vol 67, No 3 (2018)
- Pages: 558-561
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242393
- DOI: https://doi.org/10.1007/s11172-018-2110-y
- ID: 242393
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Abstract
Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.
About the authors
M. S. Borisova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: mborisova@nioch.nsc.ru
Russian Federation, 9 ul. Lavrent´evа, Novosibirsk, 630090
O. I. Yarovaya
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: mborisova@nioch.nsc.ru
Russian Federation, 9 ul. Lavrent´evа, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
M. D. Semenova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: mborisova@nioch.nsc.ru
Russian Federation, 9 ul. Lavrent´evа, Novosibirsk, 630090
T. G. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: mborisova@nioch.nsc.ru
Russian Federation, 9 ul. Lavrent´evа, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
N. F. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: mborisova@nioch.nsc.ru
Russian Federation, 9 ul. Lavrent´evа, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
