Enviar artigo por via de e-mail Antiulcerogenic activity of borneol derivatives
- Autores: Borisova M.S.1, Yarovaya O.I.1,2, Semenova M.D.1, Tolstikova T.G.1,2, Salakhutdinov N.F.1,2
-
Afiliações:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Novosibirsk State University
- Edição: Volume 67, Nº 3 (2018)
- Páginas: 558-561
- Seção: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242393
- DOI: https://doi.org/10.1007/s11172-018-2110-y
- ID: 242393
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.
Sobre autores
M. Borisova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: mborisova@nioch.nsc.ru
Rússia, 9 ul. Lavrent´evа, Novosibirsk, 630090
O. Yarovaya
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: mborisova@nioch.nsc.ru
Rússia, 9 ul. Lavrent´evа, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
M. Semenova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: mborisova@nioch.nsc.ru
Rússia, 9 ul. Lavrent´evа, Novosibirsk, 630090
T. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: mborisova@nioch.nsc.ru
Rússia, 9 ul. Lavrent´evа, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
N. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: mborisova@nioch.nsc.ru
Rússia, 9 ul. Lavrent´evа, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
Arquivos suplementares
