Antiulcerogenic activity of borneol derivatives
- 作者: Borisova M.1, Yarovaya O.1,2, Semenova M.1, Tolstikova T.1,2, Salakhutdinov N.1,2
-
隶属关系:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Novosibirsk State University
- 期: 卷 67, 编号 3 (2018)
- 页面: 558-561
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242393
- DOI: https://doi.org/10.1007/s11172-018-2110-y
- ID: 242393
如何引用文章
详细
Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.
作者简介
M. Borisova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: mborisova@nioch.nsc.ru
俄罗斯联邦, 9 ul. Lavrent´evа, Novosibirsk, 630090
O. Yarovaya
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: mborisova@nioch.nsc.ru
俄罗斯联邦, 9 ul. Lavrent´evа, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
M. Semenova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: mborisova@nioch.nsc.ru
俄罗斯联邦, 9 ul. Lavrent´evа, Novosibirsk, 630090
T. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: mborisova@nioch.nsc.ru
俄罗斯联邦, 9 ul. Lavrent´evа, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
N. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: mborisova@nioch.nsc.ru
俄罗斯联邦, 9 ul. Lavrent´evа, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090