Synthetic approaches to conjugation of aminoadamantanes and carbazoles

V. B. Sokolov; A. Yu. Aksinenko; T. A. Epishina; T. V. Goreva; S. O. Bachurin

doi:10.1007/s11172-017-1988-0

Synthetic approaches to conjugation of aminoadamantanes and carbazoles

Authors: Sokolov V.B.¹, Aksinenko A.Y.¹, Epishina T.A.¹, Goreva T.V.¹, Bachurin S.O.¹
Affiliations:
1. Institute of Physiologically Active Substances, Russian Academy of Sciences
Issue: Vol 66, No 11 (2017)
Pages: 2110-2114
Section: Full Article
URL: https://journals.rcsi.science/1066-5285/article/view/241581
DOI: https://doi.org/10.1007/s11172-017-1988-0
ID: 241581

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Abstract

Five different synthetic approaches for the conjugation of carbazoles with aminoadamantanes via propylene, 2-hydroxypropylene, 1-oxopropylene, 1-oxoethylene and triazole spacers have been proposed. The corresponding mesylate-, acrylate-, chloroacetate-, propargyl-, azido- and epoxy-containing carbazoles and aminoadamantanes were used as the starting compounds.