Conditions of catalytic hydrogenolysis for the simultaneous reduction of azido group and debenzylation of chitooligosaccharides. Synthesis of biotinylated derivatives of chitooligosaccharides


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Аннотация

Hydrogenation over Pd(OH)2/C in a methanol—water—acetic acid mixture allows one to carry out the efficient simultaneous reduction of the azido group and remove the benzyl groups in 2-azidoethyl glycosides of benzylated chitooligosaccharides. The obtained 2-aminoethyl glycosides of free chitooligosaccharides were converted to the corresponding biotinylated conjugates serving as tools for glycobiological investigations.

Авторлар туралы

O. Yudina

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: nen@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991

Yu. Tsvetkov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: nen@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991

N. Nifantiev

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: nen@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991

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