Complexation of calix[4]resorcinol with phosphorylacetic acid hydrazides possessing neurotrophic activity


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Abstract

The structures of the molecular complexes based on calix[4]resorcinol bearing a p-tolyl moiety at the lower rim with phosenazid (2-(diphenylphosphoryl)acetohydrazide) and CAPAH (2-{[4-(dimethylamino)phenyl](2-chloroethoxy)phosphoryl}acetohydrazide) were studied by NMR, IR, and UV spectroscopy and X-ray powder diffraction. The results of the screening of neurotrophic activities of the molecular complexes are presented.

About the authors

E. L. Gavrilova

Kazan National Research Technological University

Author for correspondence.
Email: gavrilova_elena_@mail.ru
Russian Federation, 68 ul. K. Marksa, Kazan, 420015

M. N. Sajfutdinova

Kazan National Research Technological University

Email: gavrilova_elena_@mail.ru
Russian Federation, 68 ul. K. Marksa, Kazan, 420015

R. I. Tarasova

Kazan National Research Technological University

Email: gavrilova_elena_@mail.ru
Russian Federation, 68 ul. K. Marksa, Kazan, 420015

N. I. Shatalova

Kazan National Research Technological University

Email: gavrilova_elena_@mail.ru
Russian Federation, 68 ul. K. Marksa, Kazan, 420015

I. I. Semina

Kazan State Medical University

Email: gavrilova_elena_@mail.ru
Russian Federation, 49 ul. Butlerova, Kazan, 420012

A. T. Gubajdullin

A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences

Email: gavrilova_elena_@mail.ru
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088


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