Functionalization of NH-unsubstituted androstano[17,16-d]pyrazoles. Synthesis of 2-arylamino-2-thioxoacetylandrostano[17,16-d]pyrazoles
- Authors: Chertkova V.V.1, Chernoburova E.I.1, Dzhafarov M.K.2, Tyurin A.Y.1, Volkova Y.A.1, Vasilevich F.I.2, Zavarzin I.V.1
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Affiliations:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
- Issue: Vol 65, No 3 (2016)
- Pages: 819-821
- Section: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/237707
- DOI: https://doi.org/10.1007/s11172-016-1381-4
- ID: 237707
Cite item
Abstract
An approach to the synthesis of earlier unknown androstano[17,16-d]pyrazoles containing a monothiooxamide fragment at the nitrogen atom of the pyrazole ring has been suggested. The method is based on the reaction of NH-unsubstituted androstano[17,16-d]pyrazole with chloroacetyl chloride with subsequent involvement of the obtained N-chloroacetylpyrazole into the reaction with elementary sulfur in the presence of aromatic amines. The synthesized androstano[17,16-d]pyrazoles containing a monothiooxamide fragment at the nitrogen atom of the pyrazole ring exhibit high antiparasitic activity.
About the authors
V. V. Chertkova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
E. I. Chernoburova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
M. Kh. Dzhafarov
K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: zavi@ioc.ac.ru
Russian Federation, 23 ul. Akad. Skryabina, Moscow, 119991
A. Yu. Tyurin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
Yu. A. Volkova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
F. I. Vasilevich
K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: zavi@ioc.ac.ru
Russian Federation, 23 ul. Akad. Skryabina, Moscow, 119991
I. V. Zavarzin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991