Functionalization of NH-unsubstituted androstano[17,16-d]pyrazoles. Synthesis of 2-arylamino-2-thioxoacetylandrostano[17,16-d]pyrazoles
- Авторы: Chertkova V.1, Chernoburova E.1, Dzhafarov M.2, Tyurin A.1, Volkova Y.1, Vasilevich F.2, Zavarzin I.1
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Учреждения:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
- Выпуск: Том 65, № 3 (2016)
- Страницы: 819-821
- Раздел: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/237707
- DOI: https://doi.org/10.1007/s11172-016-1381-4
- ID: 237707
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Аннотация
An approach to the synthesis of earlier unknown androstano[17,16-d]pyrazoles containing a monothiooxamide fragment at the nitrogen atom of the pyrazole ring has been suggested. The method is based on the reaction of NH-unsubstituted androstano[17,16-d]pyrazole with chloroacetyl chloride with subsequent involvement of the obtained N-chloroacetylpyrazole into the reaction with elementary sulfur in the presence of aromatic amines. The synthesized androstano[17,16-d]pyrazoles containing a monothiooxamide fragment at the nitrogen atom of the pyrazole ring exhibit high antiparasitic activity.
Об авторах
V. Chertkova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
E. Chernoburova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
M. Dzhafarov
K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: zavi@ioc.ac.ru
Россия, 23 ul. Akad. Skryabina, Moscow, 119991
A. Tyurin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
Yu. Volkova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
F. Vasilevich
K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: zavi@ioc.ac.ru
Россия, 23 ul. Akad. Skryabina, Moscow, 119991
I. Zavarzin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: zavi@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991