Labeling and biological evaluation of 99mTc-tricarbonyl-chenodiol for hepatobiliary imaging
- Authors: Sanad M.H.1, Sallam K.M.1, Marzook F.1
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Affiliations:
- Labeled Compounds Department, Hot Laboratories Center
- Issue: Vol 59, No 5 (2017)
- Pages: 525-529
- Section: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/224192
- DOI: https://doi.org/10.1134/S10663622170500149
- ID: 224192
Cite item
Abstract
99mTc-tricarbonyl-labeled chenodiol (chenodeoxycholic acid, CDCA) intended for hepatobiliary imaging was prepared by 30-min heating at 100°C with a radiochemical yield of >98%. The radiolabeling yield and stability of the complex were evaluated using different chromatographic techniques. Biodistribution studies in Albino Swiss mice at different time intervals after administration of the complexes showed that the maximum uptake of the complexes in the liver was 35.5 ± 0.25% ID/g at 30 min post injection. 99mTc-tricarbonyl- CDCA shows promise for hepatobiliary imaging.
About the authors
M. H. Sanad
Labeled Compounds Department, Hot Laboratories Center
Author for correspondence.
Email: drsanad74@gmail.com
Egypt, Cairo
Kh. M. Sallam
Labeled Compounds Department, Hot Laboratories Center
Email: drsanad74@gmail.com
Egypt, Cairo
F. Marzook
Labeled Compounds Department, Hot Laboratories Center
Email: drsanad74@gmail.com
Egypt, Cairo