Labeling and biological evaluation of 99mTc-tricarbonyl-chenodiol for hepatobiliary imaging
- Авторы: Sanad M.1, Sallam K.1, Marzook F.1
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Учреждения:
- Labeled Compounds Department, Hot Laboratories Center
- Выпуск: Том 59, № 5 (2017)
- Страницы: 525-529
- Раздел: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/224192
- DOI: https://doi.org/10.1134/S10663622170500149
- ID: 224192
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Аннотация
99mTc-tricarbonyl-labeled chenodiol (chenodeoxycholic acid, CDCA) intended for hepatobiliary imaging was prepared by 30-min heating at 100°C with a radiochemical yield of >98%. The radiolabeling yield and stability of the complex were evaluated using different chromatographic techniques. Biodistribution studies in Albino Swiss mice at different time intervals after administration of the complexes showed that the maximum uptake of the complexes in the liver was 35.5 ± 0.25% ID/g at 30 min post injection. 99mTc-tricarbonyl- CDCA shows promise for hepatobiliary imaging.
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Об авторах
M. Sanad
Labeled Compounds Department, Hot Laboratories Center
Автор, ответственный за переписку.
Email: drsanad74@gmail.com
Египет, Cairo
Kh. Sallam
Labeled Compounds Department, Hot Laboratories Center
Email: drsanad74@gmail.com
Египет, Cairo
F. Marzook
Labeled Compounds Department, Hot Laboratories Center
Email: drsanad74@gmail.com
Египет, Cairo