Labeling and biological evaluation of 99mTc-tricarbonyl-chenodiol for hepatobiliary imaging
- 作者: Sanad M.1, Sallam K.1, Marzook F.1
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隶属关系:
- Labeled Compounds Department, Hot Laboratories Center
- 期: 卷 59, 编号 5 (2017)
- 页面: 525-529
- 栏目: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/224192
- DOI: https://doi.org/10.1134/S10663622170500149
- ID: 224192
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详细
99mTc-tricarbonyl-labeled chenodiol (chenodeoxycholic acid, CDCA) intended for hepatobiliary imaging was prepared by 30-min heating at 100°C with a radiochemical yield of >98%. The radiolabeling yield and stability of the complex were evaluated using different chromatographic techniques. Biodistribution studies in Albino Swiss mice at different time intervals after administration of the complexes showed that the maximum uptake of the complexes in the liver was 35.5 ± 0.25% ID/g at 30 min post injection. 99mTc-tricarbonyl- CDCA shows promise for hepatobiliary imaging.
作者简介
M. Sanad
Labeled Compounds Department, Hot Laboratories Center
编辑信件的主要联系方式.
Email: drsanad74@gmail.com
埃及, Cairo
Kh. Sallam
Labeled Compounds Department, Hot Laboratories Center
Email: drsanad74@gmail.com
埃及, Cairo
F. Marzook
Labeled Compounds Department, Hot Laboratories Center
Email: drsanad74@gmail.com
埃及, Cairo