Отправить статью по E-mail Study of the Behavior of Lysozyme Oligomers in Solutions by the Molecular Dynamics Method
- Авторы: Kordonskaya Y.V.1, Timofeev V.I.1,2, Dyakova Y.A.1,2, Marchenkova M.A.1,2, Pisarevsky Y.V.1,2, Podshivalov D.D.1,2,3, Kovalchuk M.V.1,2,4
-
Учреждения:
- Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences
- National Research Centre “Kurchatov Institute,”
- Moscow State University
- St. Petersburg State University
- Выпуск: Том 63, № 6 (2018)
- Страницы: 947-950
- Раздел: Structure of Macromolecular Compounds
- URL: https://journals.rcsi.science/1063-7745/article/view/193171
- DOI: https://doi.org/10.1134/S1063774518060196
- ID: 193171
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
The dynamics of octamers of two types, which form (via translation) a tetragonal lysozyme crystal lattice, has been simulated on a 100-ns path with and without a precipitant. It is shown that one of the octamers under study is stable in the presence of a precipitant, whereas the other octamer dissociates into components both in the presence and in the absence of a precipitant. The results obtained not only confirmed the results of previous measurements of lysozyme solutions with NaCl precipitant by small-angle X-ray neutron scattering but also made it possible to establish the type of the octamer forming in the crystallization solution.
Об авторах
Yu. Kordonskaya
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences
Автор, ответственный за переписку.
Email: yukord@mail.ru
Россия, Moscow, 119333
V. Timofeev
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Россия, Moscow, 119333; Moscow, 123182
Yu. Dyakova
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Россия, Moscow, 119333; Moscow, 123182
M. Marchenkova
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Россия, Moscow, 119333; Moscow, 123182
Yu. Pisarevsky
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Россия, Moscow, 119333; Moscow, 123182
D. Podshivalov
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”; Moscow State University
Email: yukord@mail.ru
Россия, Moscow, 119333; Moscow, 123182; Moscow, 119991
M. Kovalchuk
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”; St. Petersburg State University
Email: yukord@mail.ru
Россия, Moscow, 119333; Moscow, 123182; St. Petersburg, 199034
Дополнительные файлы
