Email this article Study of the Behavior of Lysozyme Oligomers in Solutions by the Molecular Dynamics Method
- Authors: Kordonskaya Y.V.1, Timofeev V.I.1,2, Dyakova Y.A.1,2, Marchenkova M.A.1,2, Pisarevsky Y.V.1,2, Podshivalov D.D.1,2,3, Kovalchuk M.V.1,2,4
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Affiliations:
- Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences
- National Research Centre “Kurchatov Institute,”
- Moscow State University
- St. Petersburg State University
- Issue: Vol 63, No 6 (2018)
- Pages: 947-950
- Section: Structure of Macromolecular Compounds
- URL: https://journals.rcsi.science/1063-7745/article/view/193171
- DOI: https://doi.org/10.1134/S1063774518060196
- ID: 193171
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Abstract
The dynamics of octamers of two types, which form (via translation) a tetragonal lysozyme crystal lattice, has been simulated on a 100-ns path with and without a precipitant. It is shown that one of the octamers under study is stable in the presence of a precipitant, whereas the other octamer dissociates into components both in the presence and in the absence of a precipitant. The results obtained not only confirmed the results of previous measurements of lysozyme solutions with NaCl precipitant by small-angle X-ray neutron scattering but also made it possible to establish the type of the octamer forming in the crystallization solution.
About the authors
Yu. V. Kordonskaya
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences
Author for correspondence.
Email: yukord@mail.ru
Russian Federation, Moscow, 119333
V. I. Timofeev
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Russian Federation, Moscow, 119333; Moscow, 123182
Yu. A. Dyakova
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Russian Federation, Moscow, 119333; Moscow, 123182
M. A. Marchenkova
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Russian Federation, Moscow, 119333; Moscow, 123182
Yu. V. Pisarevsky
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Russian Federation, Moscow, 119333; Moscow, 123182
D. D. Podshivalov
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”; Moscow State University
Email: yukord@mail.ru
Russian Federation, Moscow, 119333; Moscow, 123182; Moscow, 119991
M. V. Kovalchuk
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”; St. Petersburg State University
Email: yukord@mail.ru
Russian Federation, Moscow, 119333; Moscow, 123182; St. Petersburg, 199034
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