Study of the Behavior of Lysozyme Oligomers in Solutions by the Molecular Dynamics Method


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Аннотация

The dynamics of octamers of two types, which form (via translation) a tetragonal lysozyme crystal lattice, has been simulated on a 100-ns path with and without a precipitant. It is shown that one of the octamers under study is stable in the presence of a precipitant, whereas the other octamer dissociates into components both in the presence and in the absence of a precipitant. The results obtained not only confirmed the results of previous measurements of lysozyme solutions with NaCl precipitant by small-angle X-ray neutron scattering but also made it possible to establish the type of the octamer forming in the crystallization solution.

Авторлар туралы

Yu. Kordonskaya

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: yukord@mail.ru
Ресей, Moscow, 119333

V. Timofeev

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”

Email: yukord@mail.ru
Ресей, Moscow, 119333; Moscow, 123182

Yu. Dyakova

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”

Email: yukord@mail.ru
Ресей, Moscow, 119333; Moscow, 123182

M. Marchenkova

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”

Email: yukord@mail.ru
Ресей, Moscow, 119333; Moscow, 123182

Yu. Pisarevsky

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”

Email: yukord@mail.ru
Ресей, Moscow, 119333; Moscow, 123182

D. Podshivalov

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”; Moscow State University

Email: yukord@mail.ru
Ресей, Moscow, 119333; Moscow, 123182; Moscow, 119991

M. Kovalchuk

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”; St. Petersburg State University

Email: yukord@mail.ru
Ресей, Moscow, 119333; Moscow, 123182; St. Petersburg, 199034

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