Enviar artigo por via de e-mail Study of the Behavior of Lysozyme Oligomers in Solutions by the Molecular Dynamics Method
- Autores: Kordonskaya Y.V.1, Timofeev V.I.1,2, Dyakova Y.A.1,2, Marchenkova M.A.1,2, Pisarevsky Y.V.1,2, Podshivalov D.D.1,2,3, Kovalchuk M.V.1,2,4
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Afiliações:
- Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences
- National Research Centre “Kurchatov Institute,”
- Moscow State University
- St. Petersburg State University
- Edição: Volume 63, Nº 6 (2018)
- Páginas: 947-950
- Seção: Structure of Macromolecular Compounds
- URL: https://journals.rcsi.science/1063-7745/article/view/193171
- DOI: https://doi.org/10.1134/S1063774518060196
- ID: 193171
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Resumo
The dynamics of octamers of two types, which form (via translation) a tetragonal lysozyme crystal lattice, has been simulated on a 100-ns path with and without a precipitant. It is shown that one of the octamers under study is stable in the presence of a precipitant, whereas the other octamer dissociates into components both in the presence and in the absence of a precipitant. The results obtained not only confirmed the results of previous measurements of lysozyme solutions with NaCl precipitant by small-angle X-ray neutron scattering but also made it possible to establish the type of the octamer forming in the crystallization solution.
Sobre autores
Yu. Kordonskaya
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences
Autor responsável pela correspondência
Email: yukord@mail.ru
Rússia, Moscow, 119333
V. Timofeev
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Rússia, Moscow, 119333; Moscow, 123182
Yu. Dyakova
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Rússia, Moscow, 119333; Moscow, 123182
M. Marchenkova
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Rússia, Moscow, 119333; Moscow, 123182
Yu. Pisarevsky
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: yukord@mail.ru
Rússia, Moscow, 119333; Moscow, 123182
D. Podshivalov
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”; Moscow State University
Email: yukord@mail.ru
Rússia, Moscow, 119333; Moscow, 123182; Moscow, 119991
M. Kovalchuk
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”; St. Petersburg State University
Email: yukord@mail.ru
Rússia, Moscow, 119333; Moscow, 123182; St. Petersburg, 199034
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