Email this article Application of the DBSCAN Algorithm to Detect Hydrophobic Clusters in Protein Structures
- Authors: Lashkov A.A.1, Rubinsky S.V.1, Eistrikh-Heller P.A.1
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Affiliations:
- Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences
- Issue: Vol 64, No 3 (2019)
- Pages: 524-532
- Section: Software
- URL: https://journals.rcsi.science/1063-7745/article/view/194042
- DOI: https://doi.org/10.1134/S1063774519030179
- ID: 194042
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Abstract
Hydrophobic cores and hydrophobic clusters play a key role in globular protein folding, providing a framework for functionally important amino acid residues of proteins and enzymes. A program was developed for clustering amino acid residues in protein structures, which takes into account their hydrophobicity and utilizes the DBSCAN algorithm. The program is described and its scope and applicability are outlined.
About the authors
A. A. Lashkov
Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences
Author for correspondence.
Email: alashkov83@gmail.com
Russian Federation, Moscow, 119333
S. V. Rubinsky
Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences
Email: alashkov83@gmail.com
Russian Federation, Moscow, 119333
P. A. Eistrikh-Heller
Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences
Email: alashkov83@gmail.com
Russian Federation, Moscow, 119333
