Effects of Indralin on Immunohematological Parameters and DNA Damage in Irradiated ICR (CD-1) Outbred Mice
- Авторы: Bushmanov A.1, Osipov A.1,2, Ignatov M.1, Vorontsova M.1, Karaulova T.1, Gordeev A.1, Yashkina E.1, Nikitenko O.1,3, Bychkova T.1,3, Stavrakova N.1, Andrianova I.1, Blokhina T.1,2, Vorobyeva N.1,2, Ivanov A.1,3,4
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Учреждения:
- State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
- Semenov Institute of Chemical Physics, Russian Academy of Sciences
- Federal State Budgetary Institution of Science “Russian Federation State Scientific Center—Institute of Biomedical Problems,” Russian Academy of Sciences
- Joint Institute for Nuclear Research
- Выпуск: Том 46, № 11 (2019)
- Страницы: 1564-1570
- Раздел: Modification of Radiation Effects
- URL: https://journals.rcsi.science/1062-3590/article/view/183391
- DOI: https://doi.org/10.1134/S1062359019110104
- ID: 183391
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Аннотация
Abstract—Intragastric administration of radioprotector indralin (B-190 drug) to outbred SPF ICR (CD-1) mice 15 minutes before X-ray irradiation at doses of 6 Gy (LD-10/30), 6.5 Gy, and 7 Gy (LD-100/30) increases the 30-day survival of the animals and positively affects the state of the central organs of immunity and hematopoiesis, as well as the number of peripheral blood leukocytes. In addition, a positive effect on the behavioral reactions of the irradiated animals and striated muscles strength was noted. In addition to these secondary features of the indralin positive effect, a significant reduction of radiation-induced DNA damage in spleenocytes was observed using flow cytometry analysis of phosphorylated histone Н2АХ (γН2АХ) (1 h and eight days after X-ray irradiation) and DNA-comet assay (eight days after X-ray irradiation). The abovementioned methods are recommended for experiments investigating the influence of radioprotective drugs on DNA damage induction and repair in the irradiated organism, as well as for initial searching of potential radioprotectors and assessment of their effectiveness level in clinical practice and experiments.
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Об авторах
A. Bushmanov
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: a1931192@mail.ru
Россия, Moscow
A. Osipov
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: a1931192@mail.ru
Россия, Moscow; Moscow
M. Ignatov
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: a1931192@mail.ru
Россия, Moscow
M. Vorontsova
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: a1931192@mail.ru
Россия, Moscow
T. Karaulova
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: a1931192@mail.ru
Россия, Moscow
A. Gordeev
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: a1931192@mail.ru
Россия, Moscow
E. Yashkina
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: a1931192@mail.ru
Россия, Moscow
O. Nikitenko
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Federal State Budgetary Institution of Science “Russian Federation State Scientific Center—Institute of Biomedical Problems,” Russian Academy of Sciences
Email: a1931192@mail.ru
Россия, Moscow; Moscow
T. Bychkova
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Federal State Budgetary Institution of Science “Russian Federation State Scientific Center—Institute of Biomedical Problems,” Russian Academy of Sciences
Email: a1931192@mail.ru
Россия, Moscow; Moscow
N. Stavrakova
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: a1931192@mail.ru
Россия, Moscow
I. Andrianova
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: a1931192@mail.ru
Россия, Moscow
T. Blokhina
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: a1931192@mail.ru
Россия, Moscow; Moscow
N. Vorobyeva
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: a1931192@mail.ru
Россия, Moscow; Moscow
A. Ivanov
State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Federal State Budgetary Institution of Science “Russian Federation State Scientific Center—Institute of Biomedical Problems,” Russian Academy of Sciences; Joint Institute for Nuclear Research
Автор, ответственный за переписку.
Email: a1931192@mail.ru
Россия, Moscow; Moscow; Dubna