Rapid Screening and Determination of Residual Veterinary Drugs in Milk by Ultrahigh Performance Liquid Chromatography–High-Resolution Quadrupole Time-of-Flight Mass Spectrometry
- 作者: Amelin V.1,2, Fedina N.1, Podkolzin I.1, Korotkov A.2,3
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隶属关系:
- Federal Centre for Animal Health
- Vladimir State University
- Bryansk Interregional Veterinary Laboratory
- 期: 卷 73, 编号 6 (2018)
- 页面: 576-585
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183063
- DOI: https://doi.org/10.1134/S1061934818060023
- ID: 183063
如何引用文章
详细
A rapid screening and determination of 150 veterinary drugs of various classes in milk by UHPLC–high-resolution quadrupole time-of-flight mass spectrometry is proposed. One gram of milk was used for the analysis; the precipitation of proteins and extraction were performed with acetonitrile; the extract was analyzed without purification or preconcentration. Veterinary drugs were identified by accurate masses of analyte ions produced by electrospray ionization, their retention time, and the pattern of ion isotope distribution (mSigma). The quantitative analysis of the detected analytes was carried out by the standard addition method. The limits of detection were 0.1–0.5 ng/g; the analytical ranges were (0.1)1–500 ng/g; the duration of screening was 20–30 min; and the analysis time was 30–40 min. The relative standard deviation of the results for all analytes did not exceed 15%.
作者简介
V. Amelin
Federal Centre for Animal Health; Vladimir State University
编辑信件的主要联系方式.
Email: amelinvg@mail.ru
俄罗斯联邦, Yur’evets, Vladimir, 600901; Vladimir, 600000
N. Fedina
Federal Centre for Animal Health
Email: amelinvg@mail.ru
俄罗斯联邦, Yur’evets, Vladimir, 600901
I. Podkolzin
Federal Centre for Animal Health
Email: amelinvg@mail.ru
俄罗斯联邦, Yur’evets, Vladimir, 600901
A. Korotkov
Vladimir State University; Bryansk Interregional Veterinary Laboratory
Email: amelinvg@mail.ru
俄罗斯联邦, Vladimir, 600000; Suponevo, Bryansk oblast, 241520
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