Determination of Non-Narcotic Analgetics by HPLC with Preconcentration on Triton X-100 Induced Phases
- 作者: Fedorchuk O.1, Kulichenko S.1
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隶属关系:
- Chemistry Department, Taras Shevchenko Kiev National University
- 期: 卷 73, 编号 9 (2018)
- 页面: 917-921
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182835
- DOI: https://doi.org/10.1134/S1061934818090022
- ID: 182835
如何引用文章
详细
The induced micellar-extraction preconcentration of mefenamic acid, naproxen, and indomethacin on Triton X-100 phases in the presence of salicylic and benzoic acids is studied. The optimal conditions for the preconcentration of analgetics are found: the pH of the solutions and the concentration of analytes. The maximum extraction of analgetics is observed at pH < pKa of the analyte and modifier. An increase in the recovery of analgetics with a decrease in their concentration in the initial solution is shown. A procedure for the determination of non-narcotic analgetics by HPLC with preliminary micellar-extraction concentration on Triton X-100 induced phases is developed. The procedure was used to analyze an urine sample with additives.
作者简介
O. Fedorchuk
Chemistry Department, Taras Shevchenko Kiev National University
编辑信件的主要联系方式.
Email: olga8182@gmail.com
乌克兰, Kiev, 01601
S. Kulichenko
Chemistry Department, Taras Shevchenko Kiev National University
Email: olga8182@gmail.com
乌克兰, Kiev, 01601
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