Determination of Non-Narcotic Analgetics by HPLC with Preconcentration on Triton X-100 Induced Phases
- Autores: Fedorchuk O.1, Kulichenko S.1
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Afiliações:
- Chemistry Department, Taras Shevchenko Kiev National University
- Edição: Volume 73, Nº 9 (2018)
- Páginas: 917-921
- Seção: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182835
- DOI: https://doi.org/10.1134/S1061934818090022
- ID: 182835
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Resumo
The induced micellar-extraction preconcentration of mefenamic acid, naproxen, and indomethacin on Triton X-100 phases in the presence of salicylic and benzoic acids is studied. The optimal conditions for the preconcentration of analgetics are found: the pH of the solutions and the concentration of analytes. The maximum extraction of analgetics is observed at pH < pKa of the analyte and modifier. An increase in the recovery of analgetics with a decrease in their concentration in the initial solution is shown. A procedure for the determination of non-narcotic analgetics by HPLC with preliminary micellar-extraction concentration on Triton X-100 induced phases is developed. The procedure was used to analyze an urine sample with additives.
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Sobre autores
O. Fedorchuk
Chemistry Department, Taras Shevchenko Kiev National University
Autor responsável pela correspondência
Email: olga8182@gmail.com
Ucrânia, Kiev, 01601
S. Kulichenko
Chemistry Department, Taras Shevchenko Kiev National University
Email: olga8182@gmail.com
Ucrânia, Kiev, 01601
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