Voltammetric determination of paracetamol at NiO nanoparticles-modified carbon paste electrode in bulk and tablet dosage forms
- 作者: Naeemy A.1,2, Mohammadi A.1,2,3, Assi N.1
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隶属关系:
- Department of Drug and Food Control, Faculty of Pharmacy
- Pharmaceutical Quality Assurance Research Center, Faculty of Pharmacy
- Nanotechnology Research Centre, Faculty of Pharmacy
- 期: 卷 72, 编号 7 (2017)
- 页面: 783-792
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182563
- DOI: https://doi.org/10.1134/S1061934817070024
- ID: 182563
如何引用文章
详细
Nickel oxide (NiO) nanoparticles were synthesized by a rapid method and well characterized. The nanoparticles were then used with graphite powder to prepare modified carbon paste electrode (CPE/NiO) for electrocatalytic oxidation of paracetamol (AC). The CPE/NiO showed higher electrocatalytic activity than nickel rod electrode in electrocatalytic oxidation of AC in alkaline media. The assay of AC, mechanism and kinetics of the electrooxidation process were investigated by cyclic voltammetry and chronoamperometry. The catalytic rate constant and the charge transfer coefficient of AC electrooxidation by the active nickel species and the diffusion coefficient of AC were also reported. The linear dependence of the peak current on the concentration of the AC was observed in the range 2–14 mM. This procedure was successfully applied to the determination of AC in tablets. The results showed sufficient precision, accuracy and achieved a mean recovery of 97.2% (RSD = 6.7%).
作者简介
Ali Naeemy
Department of Drug and Food Control, Faculty of Pharmacy; Pharmaceutical Quality Assurance Research Center, Faculty of Pharmacy
Email: alimohammadi@tums.ac.ir
伊朗伊斯兰共和国, Tehran; Tehran
Ali Mohammadi
Department of Drug and Food Control, Faculty of Pharmacy; Pharmaceutical Quality Assurance Research Center, Faculty of Pharmacy; Nanotechnology Research Centre, Faculty of Pharmacy
编辑信件的主要联系方式.
Email: alimohammadi@tums.ac.ir
伊朗伊斯兰共和国, Tehran; Tehran; Tehran
Navid Assi
Department of Drug and Food Control, Faculty of Pharmacy
Email: alimohammadi@tums.ac.ir
伊朗伊斯兰共和国, Tehran
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