Voltammetric determination of paracetamol at NiO nanoparticles-modified carbon paste electrode in bulk and tablet dosage forms
- Authors: Naeemy A.1,2, Mohammadi A.1,2,3, Assi N.1
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Affiliations:
- Department of Drug and Food Control, Faculty of Pharmacy
- Pharmaceutical Quality Assurance Research Center, Faculty of Pharmacy
- Nanotechnology Research Centre, Faculty of Pharmacy
- Issue: Vol 72, No 7 (2017)
- Pages: 783-792
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182563
- DOI: https://doi.org/10.1134/S1061934817070024
- ID: 182563
Cite item
Abstract
Nickel oxide (NiO) nanoparticles were synthesized by a rapid method and well characterized. The nanoparticles were then used with graphite powder to prepare modified carbon paste electrode (CPE/NiO) for electrocatalytic oxidation of paracetamol (AC). The CPE/NiO showed higher electrocatalytic activity than nickel rod electrode in electrocatalytic oxidation of AC in alkaline media. The assay of AC, mechanism and kinetics of the electrooxidation process were investigated by cyclic voltammetry and chronoamperometry. The catalytic rate constant and the charge transfer coefficient of AC electrooxidation by the active nickel species and the diffusion coefficient of AC were also reported. The linear dependence of the peak current on the concentration of the AC was observed in the range 2–14 mM. This procedure was successfully applied to the determination of AC in tablets. The results showed sufficient precision, accuracy and achieved a mean recovery of 97.2% (RSD = 6.7%).
About the authors
Ali Naeemy
Department of Drug and Food Control, Faculty of Pharmacy; Pharmaceutical Quality Assurance Research Center, Faculty of Pharmacy
Email: alimohammadi@tums.ac.ir
Iran, Islamic Republic of, Tehran; Tehran
Ali Mohammadi
Department of Drug and Food Control, Faculty of Pharmacy; Pharmaceutical Quality Assurance Research Center, Faculty of Pharmacy; Nanotechnology Research Centre, Faculty of Pharmacy
Author for correspondence.
Email: alimohammadi@tums.ac.ir
Iran, Islamic Republic of, Tehran; Tehran; Tehran
Navid Assi
Department of Drug and Food Control, Faculty of Pharmacy
Email: alimohammadi@tums.ac.ir
Iran, Islamic Republic of, Tehran