New possibilities of dimethylformamide dimethylacetal as a derivatization agent for gas chromatography/mass spectrometry analysis


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

It is shown that the use of dimethylformamide dimethylacetal for the derivatization of analytes in gas chromatography/mass spectrometry cannot be restricted by the known conversion of carboxylic acids, phenols, and thiols into their methyl esters (ethers), as well as by the conversion of non-volatile amino acids (and C-amino compounds of other classes) into their dimethylaminomethylene derivatives. The application of this reagent to the derivatization of hydrazine derivatives and volatile carbonyl-containing analytes is considered. In the last case, the reaction proceeds selectively via CH2 and/or CH3 groups in the α-position to the carbonyl fragment. The principal predestination of the derivatization of such analytes is their characterization by differences of gas-chromatographic retention indices (ΔRI) of reaction products and initial substrates. The ranges of variation of such increments, ΔRI, appeared to be different for different subgroups of carbonyl compounds; this allowed us to determine their structures more precisely. The mass spectra of C-dimethylaminomethylene derivatives of some carbonyl compounds, preferably 2-substituted 1-methyl- and 1-aryl-3-(dimethylamino) prop-2-en-1-ones, revealed intense [M–17] peaks. The appearance of these signals can be explained by the migration of a hydrogen atom and the formation of [М–ОН]+ ions.

作者简介

I. Zenkevich

Institute of Chemistry

编辑信件的主要联系方式.
Email: izenkevich@mail15.com
俄罗斯联邦, Petrodvorets, St. Petersburg, 198504

T. Pushkareva

Institute of Chemistry

Email: izenkevich@mail15.com
俄罗斯联邦, Petrodvorets, St. Petersburg, 198504


版权所有 © Pleiades Publishing, Ltd., 2016
##common.cookie##