Reducing and Oxidizing Columns in the Flow Injection Determination of Nitrazepam in Pharmaceutical Formulations
- Авторы: Hind Hadi 1, Mouayed M.1, Gouda A.2
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Учреждения:
- Department of Chemistry, College of Science, University of Baghdad
- Chemistry Department, Faculty of Sciences, Zagazig University
- Выпуск: Том 74, № 2 (2019)
- Страницы: 143-152
- Раздел: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183148
- DOI: https://doi.org/10.1134/S1061934819020060
- ID: 183148
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Аннотация
Two flow injection analysis (FIA) systems for determining nitrazepam (NZP) in pharmaceutical formulations using two kinds of solid-phase reactors were developed. The first system involved on-line oxidation of the reagent using a mini column containing PbO2 immobilized on cellulose acetate, while the second one involved on-line reduction of drug using a mini-Jones reductor. Both methods are based on spectrophotometric method involving oxidative coupling reaction to phenothiazine with reduced NZP in the presence of a suitable oxidizing agent to form a green color product measured at 615 or 589 nm for the two methods, respectively. The calibration graphs were linear over the range 0.5 to 45 and 10 to 250 μg/mL with a relative standard deviation less than 3.6% (n = 32) and 2.4% (n = 35) for the two methods. Solid-phase reactors can be applied for the determination of NZP in a FIA with high sensitivity and significant advantages over conventional procedures.
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Об авторах
Hind Hadi
Department of Chemistry, College of Science, University of Baghdad
Автор, ответственный за переписку.
Email: hindhadi13@yahoo.com
Ирак, Baghdad
Marwa Mouayed
Department of Chemistry, College of Science, University of Baghdad
Email: hindhadi13@yahoo.com
Ирак, Baghdad
Ayman Gouda
Chemistry Department, Faculty of Sciences, Zagazig University
Email: hindhadi13@yahoo.com
Египет, Zagazig, 44519