Novel Electrochemical Flow Injection Procedure for Albendazole Determination using Boron-doped Diamond thin Film Electrode
- Autores: Watthanachaiyapong Janhom 1, Rannurags N.1, Kongsakphaisal A.2, Sirisungworwong W.1, Liawruangrath S.1,3
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Afiliações:
- Alpha Flow Analysis Group, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University
- Department of Chemistry, Faculty of Science, King Mongkut’s Institute of Technology Ladkrabang, Chalongkrung Rd. Ladkrabang
- Material Science Research Center, Faculty of Science, Chiang Mai University
- Edição: Volume 74, Nº 5 (2019)
- Páginas: 513-519
- Seção: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183218
- DOI: https://doi.org/10.1134/S1061934819050046
- ID: 183218
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Resumo
The homemade electrochemical cell for electrochemical determination of albendazole using boron-doped diamond (BDD) thin film electrode is developed. Electrochemical activity of albendazole was investigated by cyclic voltammetry in 0.10 M phosphate buffer containing 20% (v/v) methanol at pH 2.5. Using the BDD electrode well-defined and highly reproducible cyclic voltammogram was obtained with current signal-to-background ratio of higher than those obtained from the glassy carbon electrode. Flow injection analysis system with amperometric detection using the homemade thin-layer electrochemical flow-through cell with BDD electrode was studied. The hydrodynamic voltammogram of the drug exhibited single well defined maximum oxidation peak at 0.95 V versus Ag/AgCl. A low detection limit of 2 ppm was obtained. The current–concentration relationship was rectilinear over the concentration range of 3.3‒150 ppm. The proposed method was applied to albendazole tablets with satisfactory results.
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Sobre autores
Watthanachaiyapong Janhom
Alpha Flow Analysis Group, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University
Email: scislwrn@gmail.com
Tailândia, Chiang Mai, 50200
Narabhats Rannurags
Alpha Flow Analysis Group, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University
Email: scislwrn@gmail.com
Tailândia, Chiang Mai, 50200
Arunee Kongsakphaisal
Department of Chemistry, Faculty of Science, King Mongkut’s Institute of Technology Ladkrabang,Chalongkrung Rd. Ladkrabang
Email: scislwrn@gmail.com
Tailândia, Bangkok, 10520
Wasan Sirisungworwong
Alpha Flow Analysis Group, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University
Email: scislwrn@gmail.com
Tailândia, Chiang Mai, 50200
Saisunee Liawruangrath
Alpha Flow Analysis Group, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University; Material Science Research Center, Faculty of Science, Chiang Mai University
Autor responsável pela correspondência
Email: scislwrn@gmail.com
Tailândia, Chiang Mai, 50200; Chiang Mai, 50200
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