Novel Electrochemical Flow Injection Procedure for Albendazole Determination using Boron-doped Diamond thin Film Electrode
- Authors: Watthanachaiyapong Janhom 1, Rannurags N.1, Kongsakphaisal A.2, Sirisungworwong W.1, Liawruangrath S.1,3
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Affiliations:
- Alpha Flow Analysis Group, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University
- Department of Chemistry, Faculty of Science, King Mongkut’s Institute of Technology Ladkrabang, Chalongkrung Rd. Ladkrabang
- Material Science Research Center, Faculty of Science, Chiang Mai University
- Issue: Vol 74, No 5 (2019)
- Pages: 513-519
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183218
- DOI: https://doi.org/10.1134/S1061934819050046
- ID: 183218
Cite item
Abstract
The homemade electrochemical cell for electrochemical determination of albendazole using boron-doped diamond (BDD) thin film electrode is developed. Electrochemical activity of albendazole was investigated by cyclic voltammetry in 0.10 M phosphate buffer containing 20% (v/v) methanol at pH 2.5. Using the BDD electrode well-defined and highly reproducible cyclic voltammogram was obtained with current signal-to-background ratio of higher than those obtained from the glassy carbon electrode. Flow injection analysis system with amperometric detection using the homemade thin-layer electrochemical flow-through cell with BDD electrode was studied. The hydrodynamic voltammogram of the drug exhibited single well defined maximum oxidation peak at 0.95 V versus Ag/AgCl. A low detection limit of 2 ppm was obtained. The current–concentration relationship was rectilinear over the concentration range of 3.3‒150 ppm. The proposed method was applied to albendazole tablets with satisfactory results.
About the authors
Watthanachaiyapong Janhom
Alpha Flow Analysis Group, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University
Email: scislwrn@gmail.com
Thailand, Chiang Mai, 50200
Narabhats Rannurags
Alpha Flow Analysis Group, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University
Email: scislwrn@gmail.com
Thailand, Chiang Mai, 50200
Arunee Kongsakphaisal
Department of Chemistry, Faculty of Science, King Mongkut’s Institute of Technology Ladkrabang,Chalongkrung Rd. Ladkrabang
Email: scislwrn@gmail.com
Thailand, Bangkok, 10520
Wasan Sirisungworwong
Alpha Flow Analysis Group, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University
Email: scislwrn@gmail.com
Thailand, Chiang Mai, 50200
Saisunee Liawruangrath
Alpha Flow Analysis Group, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University; Material Science Research Center, Faculty of Science, Chiang Mai University
Author for correspondence.
Email: scislwrn@gmail.com
Thailand, Chiang Mai, 50200; Chiang Mai, 50200