Determination of Aromatic Microbial Metabolites in Blood Serum by Gas Chromatography–Mass Spectrometry
- Autores: Pautova A.1, Bedova A.1, Sarshor Y.1, Beloborodova N.1
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Afiliações:
- Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
- Edição: Volume 73, Nº 2 (2018)
- Páginas: 160-166
- Seção: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182969
- DOI: https://doi.org/10.1134/S1061934818020089
- ID: 182969
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Resumo
We present the results of the determination of eight aromatic microbial metabolites, phenylcarboxylic acids (PhCAs), by gas chromatography–mass spectrometry after their liquid–liquid extraction from serum samples and derivatization. The analytical range for the analytes is 0.5–40 μM. The concentration of phenylcarboxylic acids in the serum of healthy donors (n = 40) and the time profile of the concentration of different PhCAs in serum samples of four patients from the intensive care unit (ICU) are studied. The results correlated with the severity of the clinical state of patients.
Sobre autores
A. Pautova
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Autor responsável pela correspondência
Email: alicepau@mail.ru
Rússia, Moscow, 107031
A. Bedova
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Email: alicepau@mail.ru
Rússia, Moscow, 107031
Yu. Sarshor
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Email: alicepau@mail.ru
Rússia, Moscow, 107031
N. Beloborodova
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Email: alicepau@mail.ru
Rússia, Moscow, 107031