Use of high-performance liquid chromatography coupled with high-resolution mass spectrometry for the identification and quantitative determination of tetrodotoxin in pharmaceuticals
- Autores: Shalabai V.1, Taranchenko V.1,2, Rybal’chenko I.2, Aksenov A.1, Antokhin A.1, Semchenko F.3, Krymchak M.3
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Afiliações:
- FGUP “Scientific Center “Signal”,”
- 27 Scientific Center of the Ministry of Defence of the Russian Federation
- State Pharmaceutical Plant
- Edição: Volume 72, Nº 6 (2017)
- Páginas: 632-638
- Seção: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182491
- DOI: https://doi.org/10.1134/S1061934817060144
- ID: 182491
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Resumo
A procedure is developed for the identification and determination of tetrodotoxin in pharmaceuticals by liquid chromatography coupled with high resolution mass spectrometry (HPLC−HRMS). The components of a pharmaceutical sample were separated in the gradient elution mode on a HILIC hydrophilic sorbent and detected by HRMS with electrospray ionization in the mode of registration of selected ion transitions. The calibration curve is linear in the range 0.75−1.25 μg/mL with the correlation coefficient > 0.9995.
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Sobre autores
V. Shalabai
FGUP “Scientific Center “Signal”,”
Autor responsável pela correspondência
Email: shalabay_v@outlook.com
Rússia, Moscow, 107014
V. Taranchenko
FGUP “Scientific Center “Signal”,”; 27 Scientific Center of the Ministry of Defence of the Russian Federation
Email: shalabay_v@outlook.com
Rússia, Moscow, 107014; Moscow, 105005
I. Rybal’chenko
27 Scientific Center of the Ministry of Defence of the Russian Federation
Email: shalabay_v@outlook.com
Rússia, Moscow, 105005
A. Aksenov
FGUP “Scientific Center “Signal”,”
Email: shalabay_v@outlook.com
Rússia, Moscow, 107014
A. Antokhin
FGUP “Scientific Center “Signal”,”
Email: shalabay_v@outlook.com
Rússia, Moscow, 107014
F. Semchenko
State Pharmaceutical Plant
Email: shalabay_v@outlook.com
Rússia, Moscow, 111024
M. Krymchak
State Pharmaceutical Plant
Email: shalabay_v@outlook.com
Rússia, Moscow, 111024