An Electrochemical DNA Sensor for Doxorubicin Based on a Polyelectrolyte Complex and Aminated Thiacalix[4]Arene
- Авторлар: Porfir’eva A.1, Shibaeva K.1, Evtyugin V.2, Yakimova L.1, Stoikov I.1, Evtyugin G.1
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Мекемелер:
- Butlerov Institute of Chemistry, Kazan Federal University
- Interdisciplinary Center for Analytical Microscopy, Kazan Federal University
- Шығарылым: Том 74, № 7 (2019)
- Беттер: 707-714
- Бөлім: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183254
- DOI: https://doi.org/10.1134/S1061934819070086
- ID: 183254
Дәйексөз келтіру
Аннотация
An impedimetric DNA sensor is developed for the highly sensitive determination of doxorubicin; the signal is charge transfer resistance recorded by electrochemical impedance spectroscopy using a glassy carbon electrode modified by electropolymerized Neutral Red or polyaniline and polyelectrolyte complexes including DNA. The nature of the polymer layer and the composition of the polyelectrolyte complex affect the sensitivity of the determination of doxorubicin. The role of a macrocycle capable of shielding the DNA negative charge and interacting with cationic centers of the substrate is shown. With an optimal composition of polyelectrolytes, the DNA sensor ensures the determination of down to 0.1 nM of doxorubicin.
Негізгі сөздер
Авторлар туралы
A. Porfir’eva
Butlerov Institute of Chemistry, Kazan Federal University
Хат алмасуға жауапты Автор.
Email: porfireva-a@inbox.ru
Ресей, Kazan, 420008
K. Shibaeva
Butlerov Institute of Chemistry, Kazan Federal University
Email: porfireva-a@inbox.ru
Ресей, Kazan, 420008
V. Evtyugin
Interdisciplinary Center for Analytical Microscopy, Kazan Federal University
Email: porfireva-a@inbox.ru
Ресей, Kazan, 420008
L. Yakimova
Butlerov Institute of Chemistry, Kazan Federal University
Email: porfireva-a@inbox.ru
Ресей, Kazan, 420008
I. Stoikov
Butlerov Institute of Chemistry, Kazan Federal University
Email: porfireva-a@inbox.ru
Ресей, Kazan, 420008
G. Evtyugin
Butlerov Institute of Chemistry, Kazan Federal University
Email: porfireva-a@inbox.ru
Ресей, Kazan, 420008