Macrocyclic Antibiotics as Chiral Selectors in High-Performance Liquid Chromatography and Capillary Electrophoresis
- Авторлар: Shapovalova E.1, Fedorova I.1, Anan’eva I.1, Shpigun O.1
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Мекемелер:
- Department of Chemistry, Moscow State University
- Шығарылым: Том 73, № 11 (2018)
- Беттер: 1064-1075
- Бөлім: Reviews
- URL: https://journals.rcsi.science/1061-9348/article/view/182866
- DOI: https://doi.org/10.1134/S1061934818110114
- ID: 182866
Дәйексөз келтіру
Аннотация
Data on the use of macrocyclic antibiotics (vancomycin, teicoplanin, teicoplanin aglycone, and eremomycin) for the enantioseparation of amino acids, various amino acid derivatives, α-phenylcarboxylic acids, β-blockers, and some pharmaceutical preparations in reversed-phase and polar-organic HPLC modes are summarized. It is shown that mixed chiral selectors (eremomycin–vancomycin, eremomycin–bovine serum albumin) combine the properties of two selectors. Eremomycin and macrolides (azithromycin, erythromycin, and clarithromycin) are successfully used as chiral selectors in capillary electrophoresis. Aqueous and aqueous–organic supporting electrolytes (SEs) with the addition of eremomycin or nonaqueous supporting electrolytes with the addition of a macrolide are used for enantioseparation. The use of nonaqueous supporting electrolytes decreases the adsorption of the selectors on the quartz capillary surface and enables the separation of enantiomers at a low concentration of a chiral selector. Additions of boric acid into the supporting electrolyte improve the selectivity of separation.
Авторлар туралы
E. Shapovalova
Department of Chemistry, Moscow State University
Email: irishan@mail.ru
Ресей, Moscow, 119991
I. Fedorova
Department of Chemistry, Moscow State University
Email: irishan@mail.ru
Ресей, Moscow, 119991
I. Anan’eva
Department of Chemistry, Moscow State University
Хат алмасуға жауапты Автор.
Email: irishan@mail.ru
Ресей, Moscow, 119991
O. Shpigun
Department of Chemistry, Moscow State University
Email: irishan@mail.ru
Ресей, Moscow, 119991