Potentiometric Determination of Paracetamol in Pharmaceutical Formulations by the Analyte Pulse Perturbation Technique using Belousov–Zhabotinskii Oscillating chemical Reaction
- Authors: Luiz Fernando Oliveira Maia 1, Reis E.L.2, Reis C.2, Gonçalves Reis C.D.3, de Carvalho Damasceno O.I.4, Teixeira dos Reis L.G.2
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Affiliations:
- Instituto Federal de Educação Ciência e Tecnologia do Norte de Minas Gerais
- Departamento de Química, Universidade Federal de Viçosa
- Instituto de Ciências Exatas, Universidade de Viçosa
- Colégio de Aplicação, Universidade Federal de Viçosa
- Issue: Vol 74, No 12 (2019)
- Pages: 1232-1238
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183354
- DOI: https://doi.org/10.1134/S1061934819120074
- ID: 183354
Cite item
Abstract
The present work proposes the development of an analytical procedure for paracetamol determination in pharmaceutical formulations using a system of continuous flow analysis associated with potentiometric detection allowing the study of the Belousov–Zhabotinskii (BZ) oscillating reaction. This method is based on paracetamol determination using the disturbance in the oscillation pattern of the BZ reaction promoted by this substance. The analytical curve showed the detection and quantification limits of 4 × 10–6 and 1.2 × 10–5 M, respectively. The relative standard deviation (n = 6) of the standard solution with paracetamol concentration of 6 mM was 2.3%. The analysis of real samples by the proposed and official methods (spectrophotometry/UV) showed similar results.
About the authors
Luiz Fernando Oliveira Maia
Instituto Federal de Educação Ciência e Tecnologia do Norte de Minas Gerais
Author for correspondence.
Email: luiz.maia@ifnmg.edu.br
Brazil, Salinas
Efraim Lázaro Reis
Departamento de Química, Universidade Federal de Viçosa
Email: luiz.maia@ifnmg.edu.br
Brazil, Viçosa
César Reis
Departamento de Química, Universidade Federal de Viçosa
Email: luiz.maia@ifnmg.edu.br
Brazil, Viçosa
Clausius Duque Gonçalves Reis
Instituto de Ciências Exatas, Universidade de Viçosa
Email: luiz.maia@ifnmg.edu.br
Brazil, Rio Paranaíba
Odilaine Inácio de Carvalho Damasceno
Colégio de Aplicação, Universidade Federal de Viçosa
Email: luiz.maia@ifnmg.edu.br
Brazil, Viçosa
Luís Gustavo Teixeira dos Reis
Departamento de Química, Universidade Federal de Viçosa
Email: luiz.maia@ifnmg.edu.br
Brazil, Viçosa