Potentiometric Determination of Paracetamol in Pharmaceutical Formulations by the Analyte Pulse Perturbation Technique using Belousov–Zhabotinskii Oscillating chemical Reaction

Abstract

The present work proposes the development of an analytical procedure for paracetamol determination in pharmaceutical formulations using a system of continuous flow analysis associated with potentiometric detection allowing the study of the Belousov–Zhabotinskii (BZ) oscillating reaction. This method is based on paracetamol determination using the disturbance in the oscillation pattern of the BZ reaction promoted by this substance. The analytical curve showed the detection and quantification limits of 4 × 10^–6 and 1.2 × 10^–5 M, respectively. The relative standard deviation (n = 6) of the standard solution with paracetamol concentration of 6 mM was 2.3%. The analysis of real samples by the proposed and official methods (spectrophotometry/UV) showed similar results.