Surfactant-Assisted Voltammetric Determination of Olanzapine at Amine Functionalized TiO2/Multi-Walled Carbon Nanotubes Nanocomposite

Abstract

This paper describes the development and utilization of a new nanocomposite consisting of amine-functionalized TiO₂/multi-walled carbon nanotubes and sodium dodecylsulfate for glassy carbon electrode modification. The nanocomposite was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy and scanning electron microscopy. The modified electrode was used for electrochemical characterization of olanzapine (OLZ). The efficiency of modified electrode for electrocatalytic oxidation of OLZ was studied by cyclic voltammetry and square wave voltammetry in phosphate buffer solution (pH 7.0). Using square wave voltammetry, the prepared sensor showed good sensitivity and selectivity with low overpotential for the determination of OLZ in the ranges from 0.05 to 0.1 and 0.1 to 10 μM, with a detection limit of 8 nM. The proposed method was employed for the determination of OLZ in tablet and blood serum samples without any pretreatment steps.