Determination of Hyoscine Butylbromide in Pharmaceuticals Using Ce(IV)–Na2SO3 Chemiluminescent System in Flow Injection Analysis
- Authors: Manzoor Ahmed 1, Asghar M.1, Yaqoob M.1, Ali S.1, Bibi N.2, Nabi A.1
-
Affiliations:
- Department of Chemistry, University of Balochistan
- Department of Chemistry, SardarBahadur Khan Women University
- Issue: Vol 73, No 11 (2018)
- Pages: 1098-1104
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182873
- DOI: https://doi.org/10.1134/S1061934818110059
- ID: 182873
Cite item
Abstract
A flow injection method with chemiluminescence (CL) detection has been developed for hyoscine butylbromide (HBB) determination based on an enhancement of cerium(IV)–sulphite CL reaction in an acidic medium. The method enables HBB determination in the range of 0.005–15 ppm (R2 = 0.9990, n = 10), with relative standard deviation of 2.5% (n = 12) for 0.25 ppm of HBB. The limit of detection (3s × blank) was 0.001 ppm with an injection throughput of 180 h–1. The concentration of reagents involved in the CL reaction and the key physical variables were carefully studied and optimized. The proposed procedure offered high sensitivity, simplicity and rapidity, and was successfully applied to HBB determination in pharmaceutical preparations. The results obtained were in good agreement with the conventional spectrophotometric method. The mechanism of Ce(IV)‒Na2SO3‒HBB CL reaction is also discussed.
About the authors
Manzoor Ahmed
Department of Chemistry, University of Balochistan
Email: yaqoob2001@hotmail.com
Pakistan, Quetta-87300
Muhammed Asghar
Department of Chemistry, University of Balochistan
Email: yaqoob2001@hotmail.com
Pakistan, Quetta-87300
Mohammed Yaqoob
Department of Chemistry, University of Balochistan
Author for correspondence.
Email: yaqoob2001@hotmail.com
Pakistan, Quetta-87300
Samar Ali
Department of Chemistry, University of Balochistan
Email: yaqoob2001@hotmail.com
Pakistan, Quetta-87300
Nusrat Bibi
Department of Chemistry, SardarBahadur Khan Women University
Email: yaqoob2001@hotmail.com
Pakistan, Quetta
Abdul Nabi
Department of Chemistry, University of Balochistan
Email: yaqoob2001@hotmail.com
Pakistan, Quetta-87300