One-step in-syringe dispersive liquid–liquid microextraction and GC-FID determination of trace amounts of di(2-ethylhexyl) phthalate and its metabolite in human urine samples
- Authors: Sargazi S.1, Mirzaei R.2, Rahmani M.3, Mohammadi M.1, Khammari A.1, Sheikh M.4
-
Affiliations:
- Health Promotion Research Center
- Department of Occupational Health Engineering, School of Health
- Department of Chemistry, Faculty of Sciences
- Department of Chemistry
- Issue: Vol 72, No 5 (2017)
- Pages: 557-561
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182453
- DOI: https://doi.org/10.1134/S1061934817050100
- ID: 182453
Cite item
Abstract
Di(2-ethylhexyl) phthalate (DEHP) is used as plasticizer in polyvinylchloride (PVC) plastics. Its metabolites and the parent phthalates are considered toxic. As the DEHP plasticizers are not chemically bound to PVC, they can migrate, evaporate or be leached into indoor air and atmosphere, foodstuff, and other materials. We have reported a novel, easy and available analytical method for the determination of DEHP and its metabolite, mono(2-ethylhexyl) phthalate (MEHP) in human urine samples by the in-syringe dispersive liquid–liquid microextraction method coupled with gas chromatography with flame ionization detector. The limits of detection and precision (RSD) were 2.5 μg/L and 1.4% for DEHP and 1.1 μg/L and 3.0% for MEHP, respectively. This method could be utilized for routine monitoring of the trace DEHP and MEHP in urine of human exposure to plasticizers.
Keywords
About the authors
Shahnaz Sargazi
Health Promotion Research Center
Author for correspondence.
Email: Sh.Sargazi@gmail.com
Iran, Islamic Republic of, Zahedan
Ramazan Mirzaei
Department of Occupational Health Engineering, School of Health
Email: Sh.Sargazi@gmail.com
Iran, Islamic Republic of, Mashhad
Mashaallah Rahmani
Department of Chemistry, Faculty of Sciences
Email: Sh.Sargazi@gmail.com
Iran, Islamic Republic of, Zahedan, 98135-674
Mahdi Mohammadi
Health Promotion Research Center
Email: Sh.Sargazi@gmail.com
Iran, Islamic Republic of, Zahedan
Abdolali Khammari
Health Promotion Research Center
Email: Sh.Sargazi@gmail.com
Iran, Islamic Republic of, Zahedan
Masoome Sheikh
Department of Chemistry
Email: Sh.Sargazi@gmail.com
Iran, Islamic Republic of, Zahedan