Surface modification of electrodes by carbon nanotubes and gold and silver nanoparticles in monoaminoxidase biosensors for the determination of some antidepressants
- Authors: Medyantseva E.P.1, Brusnitsyn D.V.1, Varlamova R.M.1, Maksimov A.A.1, Konovalova O.A.2, Budnikov H.C.1
-
Affiliations:
- Alexander Butlerov Institute of Chemistry
- Institute of Physics
- Issue: Vol 72, No 4 (2017)
- Pages: 362-370
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182367
- DOI: https://doi.org/10.1134/S1061934817040086
- ID: 182367
Cite item
Abstract
Surface modification of screen-printed graphite electrodes with nanostructured materials (multiwall carbon nanotubes, gold and silver nanoparticles) allow their application as supports of amperometric monoaminoxidase biosensors for the determination of antidepressant drugs (moclobemide, tianeptine, and amitriptyline). This approach improves analytical characteristics of the corresponding biosensors because of the inhibitory effect of antidepressants (two-parameter concerted inhibition) on the catalytic activity of an immobilized enzyme. The analytical capabilities of the developed biosensor types were compared. The range of working concentrations was from 5 × 10–9 to 1 × 10–4 M and the lower limit of the analytical range was of about 8 × 10–10 M. Biosensors based on electrodes modified with nanostructured materials were tested in the control of the concentration of drugs in body fluids (urine) and dosage forms.
About the authors
E. P. Medyantseva
Alexander Butlerov Institute of Chemistry
Author for correspondence.
Email: emedyant@gmail.com
Russian Federation, Kazan, 420008
D. V. Brusnitsyn
Alexander Butlerov Institute of Chemistry
Email: emedyant@gmail.com
Russian Federation, Kazan, 420008
R. M. Varlamova
Alexander Butlerov Institute of Chemistry
Email: emedyant@gmail.com
Russian Federation, Kazan, 420008
A. A. Maksimov
Alexander Butlerov Institute of Chemistry
Email: emedyant@gmail.com
Russian Federation, Kazan, 420008
O. A. Konovalova
Institute of Physics
Email: emedyant@gmail.com
Russian Federation, Kazan, 420008
H. C. Budnikov
Alexander Butlerov Institute of Chemistry
Email: emedyant@gmail.com
Russian Federation, Kazan, 420008
![](/img/style/loading.gif)