Methods for the determination of local anesthetic agents

Abstract

The main methods for the determination of local anesthetics are considered, and their advantages and disadvantages are discussed. After the systematization of published data, it was established that the greatest number of works were devoted to the determination of novocaine, lidocaine, and ultracaine; therefore, methods for their determination are considered separately. It was demonstrated that the extraction and sorption preconcentration of local anesthetics as ion associates with chromogenic organic reagents is promising. It was substantiated that the development of combined rapid and sensitive extraction-photometric, sorptionspectroscopic, and colorimetric methods for the determination of novocaine, lidocaine, and ultracaine with chromogenic organic reagents in different test materials is a problem of considerable current interest.