Synthesis and Use of Thin Polymer Films with Molecular Imprints of Salbutamol in Quartz Crystal Microbalance Sensors

Abstract

Thin-film coatings of quartz crystal microbalance sensors with molecularly imprinted salbutamol are synthesized by photopolymerization using methacrylic acid and ethylene glycol dimethacrylate as functional and cross-monomers. The effects of the concentration of salbutamol and functional and cross-monomers in the prepolymerization mixture on the concentration of surface molecular imprints and the stability of the polymer layer with molecular imprints are shown. The conditions of the synthesis of polymer layers directly on the surface of the sensor electrode are optimized. Analytical characteristics of the sensor for the determination of salbutamol in aqueous solutions are calculated.