Determination of Fluvoxamine in Real Samples using Carbon Paste Electrode Modified by Electrodeposition of Nickel

Abstract

In this study, we reported an effective electrochemical sensor for determination of antidepressant drug fluvoxamine using carbon paste electrode modified by nickel nanoparticles deposited on the surface of electrode by electrodeposition from micellar solution. The effective parameters at response of electrode to the drug, such as surfactant concentration, applied potential and duration of potential applying for deposition of nickel on the surface of carbon paste electrode were optimized. The modified electrode was characterized by scanning electron microscopy and energy-dispersive X-ray spectroscopy methods. Electrocatalytic oxidation of fluvoxamine at the surface of modified electrode was studied using cyclic voltammetry, chronoamperometry and chronocoulometry methods. The peak currents and concentrations of fluvoxamine show a good linear response in the range form 1.2 × 10^–6–2 × 10^–4 M (R² = 0.9988). The method was successfully applied for determination of fluvoxamine in pharmaceutical sample and human blood plasma.