A Criterion of Selection of Stationary Phases for Improving the Performance of Chromatographic Analysis

Abstract

A convenient criterion is derived for the characterization of chromatographic stationary phases capable of providing an efficient and rapid analysis of a given class of mixtures based on a theoretical analysis of the dependence of specific efficiency on capacity. The criterion implicitly contains information about the internal structure of the column packing grain. The derivation of an expression for the criterion is accompanied by a theoretical substantiation of the interval for the working grain size of the column packing, which has a capacity and represents the region of particle diffusion. It is shown that the ratios are universal regardless of the type of the chromatographic process. A new characteristic of the quality of column packing can be called its performance factor, which shows the ratio of the actual to the maximum performance of the chromatographic system with a given selectivity. Examples of determining the quality criterion of a stationary phase for ion chromatography are given.