Possibility of Comparison of the Similar Pharmaceuticals from Different Producers by Spectroscopic System Based on Hollow-Core Photonic-Crystal Fiber

Abstract

The results of complex studies of a possibility of the rapid analysis of solutions using a spectroscopic system based on a hollow-core photonic-crystal fiber are presented. Pharmaceutical preparations of vitamins B and C from various manufacturers were selected as test samples. The transformation of the transmission spectra of the fiber after filling hollow channels with an analyte solution was observed in the wavelength region of 350–1100 nm, depending on the type of the vitamin, producer, and concentration. Comparative quantitative estimates of the sensitivity, resolution, and error in determining the concentration of solutions are given. To increase the functionality of the spectroscopic system, it is suggested to use known chemometric methods and algorithms.