Highly sensitive determination of 1,1-dimethylhydrazine by high-performance liquid chromatography–tandem mass spectrometry with precolumn derivatization by phenylglyoxal
- Authors: Osipenko S.V.1, Smirnov R.S.1, Smolenkov A.D.1, Shpigun O.A.1
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Affiliations:
- Department of Chemistry
- Issue: Vol 71, No 13 (2016)
- Pages: 1228-1232
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182210
- DOI: https://doi.org/10.1134/S1061934816130098
- ID: 182210
Cite item
Abstract
A new highly sensitive and rapid approach to the determination of 1,1-dimethylhydrazine in natural water is developed (determination range is 0.03–1 μg/L). It is based on the use of high-performance liquid chromatography–tandem mass spectrometry with precolumn derivatization by phenylglyoxal and does not require any preconcentration. Derivatization, chromatographic separation conditions, and tandem mass spectrometry detection parameters are chosen. Intra-day precision of the results of measurements of 1,1- dimethylhydrazine in natural water is 12–16%, and inter-day precision is 16–22%. The lowest limit of detection and the lowest limit of quantification are 0.010 μg/L and 0.030 μg/L, respectively.
About the authors
S. V. Osipenko
Department of Chemistry
Author for correspondence.
Email: osipenko@analyt.chem.msu.ru
Russian Federation, Moscow, 119991
R. S. Smirnov
Department of Chemistry
Email: osipenko@analyt.chem.msu.ru
Russian Federation, Moscow, 119991
A. D. Smolenkov
Department of Chemistry
Email: osipenko@analyt.chem.msu.ru
Russian Federation, Moscow, 119991
O. A. Shpigun
Department of Chemistry
Email: osipenko@analyt.chem.msu.ru
Russian Federation, Moscow, 119991
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