POLYMORPHIC VARIANTS DRD4 DOPAMINE RECEPTOR GENE AMONG CONSUMERS AND NON-CONSUMERS OF SYNTHETIC CATHINONE


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Abstract

We have analyzed DRD4 120bp VNTR samples provided by 181 patients suffering from cathinone addiction (case 1) and compared them to the samples taken from 168 somatically and psychologically healthy people (case 2). The analysis showed DRD4*L (120bp dup) as the most common allele in both cases. However, the frequency of the genotype *S/*S happened to be statistically more significant in case 1 compared to case 2. Based on this analysis, it could be concluded that the genetic effect on developing an addition to synthetic cathinone can be mediated via dopaminergic system, in particular by DRD4 120bp VNTR.

About the authors

Azat R Asadullin

1) Federal State Educational Institution of Higher Education Bashkir State Medical University; 2) SBHI Republican Narcological Dispensary №1 Ministry of Health Republic of Bashkortostan

Email: droar@yandex.ru
Ufa, 3 Lenin Street; Ufa, 119 Pushkin Street

Vladimir L Yuldashev

Federal State Educational Institution of Higher Education Bashkir State Medical University

Ufa, 3 Lenin Street

Ivan V Nikolaev

SBHI Republican Narcological Dispensary №1 Ministry of Health Republic of Bashkortostan

Ufa, 119 Pushkin Street

Elvina A Akhmetova

1) Federal State Educational Institution of Higher Education Bashkir State Medical University; 2) SBHI Republican Narcological Dispensary №1 Ministry of Health Republic of Bashkortostan

1) Ufa, 3 Lenin Street; 2) Ufa, 119 Pushkin Street

Siren’ A Khalikov

FSBHI Republican Narcological Dispensary №1 Ministry of Health Republic of Tatarstan

Republic of Tatarstan, Tatarstan, Almetyevsk district, urban village Lower Maktama, 1a Industrial Street

References

  1. Анохина И.П., Кибитов А.О., Шамакина И.Ю. Генетика зависимости от психоактивных веществ / Наркология: национальное руководство. М.: ГЭОТАР-Медиа, 2008. С. 56-58.
  2. Асадуллин А.Р., Ахметова Э.А., Ненастьева А.Ю. Динамика распространенности синтетических катинонов в Республике Башкортостан. Эпидемиологическая и клиническая картины // Неврологический вестник. 2016. № 4. С. 16-19.
  3. Кибитов А. О. Генетика наркологических заболеваний: молекулярно-генетический профиль дофаминовой нейромедиаторной системы при алкоголизме и опийной наркомании // Наркология. 2011. № 9. С. 25-42.
  4. Менделевич В.Д. Психотические расстройства в результате употребления наркотиков: современное состояние проблемы // Наркология. 2014. №7. 93-100.
  5. Юлдашев В.Л., Асадуллин А.Р., Галеева Е.Х. и др. Особенности распространенности и потребления синтетических дизайнерских наркотических средств на территории Республики Башкортостан // Сибирский вестник психиатрии и наркологии. 2016. № 3. С. 69-75.
  6. Al-Motarreb A., Al-Habori M., Broadley K. J. Khat chewing, cardiovascular diseases and other internal medical problems: the current situation and directions for future research // Journal of ethnopharmacology. 2010. № 3. P. 540-548.
  7. Archer R.P. Fluoromethcathinone, a new substance of abuse // Forensic Science International. 2009. № 1. P. 10-20.
  8. Blum K., Sheridan P.J., Wood R.C. et al. Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behavior // Pharmacogenetics and Genomics. 1995. №3. P. 121-141.
  9. Comings D.E., Gade R., Wu S. et al. Studies of the potential role of the dopamine D 1 receptor gene in addictive behaviors // Molecular psychiatry. 1997. № 1.P. 44-56.
  10. Faraone S. V. et al. Meta-analysis of the association between the 7-repeat allele of the dopamine D4 receptor gene and attention deficit hyperactivity disorder // American Journal of Psychiatry. 2001. 158. №. 7. P. 1052-1057.
  11. Google. Insights for search (2016) http://www.google.com/ insights/search/. Last accessed 11/02/2017.
  12. Hutchison K. E. et al. The DRD4 VNTR polymorphism influences reactivity to smoking cues // Journal of abnormal psychology. 2002. № 1. P. 134.
  13. Kelly M.A. Rubinstein M., Phillips T.J. et al. Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adapta-tions // Journal of Neuroscience. 1998. № 9. P. 3470-3479.
  14. Lerman C., Jepson C. , Wileyto E.P. et al. Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials // Neuropsychopharmacology. 2006. № 1. P. 231-242.
  15. Mathew C.C. The isolation of high molecular weight eukaryotic DNA. Methods molecular biology. N.Y., 1984. Vol. 2. P. 31-34
  16. Powell S.B, Lehmann-Masten V.D, Paulus M.P. et al. MDMA ‘ecstasy’ alters hyperactive and perseverative behaviors in dopamine transporter knockout mice // Psychopharmacology (Berlin). 2004. № 173. P. 310-317.
  17. Powell S.B., Dargan P.I., Smyllie M. et al. MDMA “ecstasy” alters hyperactive and perseverative behaviors in dopamine transporter knockout mice // Psychopharmacology. 2004. № 3-4. P. 310-317.
  18. Room H., Hotel S.B. American Association of Poison Control Centers // Сlinical toxicology. 1974. № 4. P. 433-438.
  19. Shao C. et al. Dopamine D4 receptor polymorphism modulates cue-elicited heroin craving in Chinese // Psychopharmacology. 2006. №. 2. P. 185-190.
  20. Schoots O., Van Tol H.H.M. The human dopamine D4 receptor repeat sequences modulate expression // The pharmacogenomics journal. 2003. № 6. P. 343-348.
  21. Strano-Rossi S., Cadwallader A.B., de la Torre X., Botrè F. Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MPDV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry // Rapid Communications in Mass Spectrometry. 2010. № 18. P. 2706-2714.
  22. Spiller H.A. Ryan M.L., Weston R.G., Jansen J. Clinical experience with and analytical confirmation of “bath salts” and “legal highs”(synthetic cathinones) in the United States // Clinical toxicology. 2011. № 6. P. 499-505.
  23. Van Tol H.H., Wu C.M., Guan H.C. et al. Multiple dopamine D4 receptor variants in the human population // Nature. 1992. № 358. P. 9.
  24. Yamamoto B.K., Spanos L.J. The acute effects of methylenedioxymethamphetamine on dopamine release in the wakebehaving rat // Eur J Pharmacol. 1988. № 148. P. 195-203.

Copyright (c) 2017 Asadullin A.R., Yuldashev V.L., Nikolaev I.V., Akhmetova E.A., Khalikov S.A.

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