Electrophysiologic study of denervational and reinnervational changes of synaptic functions in the skeletal muscle

The mechanisms of change of the neuromuscular synapse function, in the process of denervation and reinnervation are investigated in éxperiments on skin and sternal muscles of frogs using electrophysiologic and morphologic methods. It is shown that denervational and reinnervational changes are concerned just as with pre- and so with postsynaptic membranes. Postsynaptic changes are connected with change of cholinoreceptors density and substitution of normal ones for cholinoreceptors typical of the denervational muscle, and presynaptic changes are defined by ion channels degradation in denervation followed by fitting them into thenerve ending membrane in reinnervation. The density of ion channels responsible for the formation and performance of action potential, the entry of calcium ions and mediator secretion is identical in the course of the regenerating nerve ending distinguishing it from the normal one. Calcium-activated potassium channels fit in the end reinnervation stages.