Genetic aspects of neurogenic syncopes

The incidence of syncopal states in representative choice of 3209 Kazan pupils is improved, and the role of hereditary factors in the genesis of neurogenic syncopes based on the clinicogenealogical analysis of 115 families using mathematical- and-genetic investigation methods is defined concretely. As many as 91.4% syncopal states in the population studied are assessed as neurogenic syncopes (population rate — 6.4%). The disease may be assigned to the familial forms of pathology conforming to the basic characteristics of multifactorial diseases with sufficiently high (73.5%) role of genetic factors. In case of the marriage of parents «patient-patient» the observed segregational rate (0.43) of neurogenic syncopes approaches the expected one (0.50) which does not eliminate the dominant model of monogenous disease.