Neurology Bulletin

Journal topics: clinical and basic research in neurology and neurosciences.

Editor-in-Chief: V. D. Mendelevich, MD, PhD, professor.


Journal mission

The Neurological Bulletin is an academic peer-review journal for clinical and basic research results presentation in neurology and neurosciences. 

The editorial board accepts manuscripts that reflect the results of field and experimental studies, and fundamental research of broad conceptual and/or comparative context.

Publications of the journal would be of interest to a wide range of specialists in the fields of clinical neurology, neurobiology, neurochemistry, neurosciences, as well as for physicians and teachers and students of various biological and medical profiles.

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Vol LV, No 2 (2023)

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“Semantic void” of some of psychiatric terms used in the diagnosis of schizophrenia
Mendelevich V.D.

The article is devoted to an analysis of the terminology used to support a psychiatric diagnosis. Using linguistic approaches, the author draws attention to the presence in psychiatry of “semantically filled” and “semantically empty” terms that denote certain psychopathological symptoms/signs.

It is concluded that for a number of terms used in the diagnosis of schizophrenia spectrum disorders, a revision should be revised and those that are vague, ambiguous, not included in international diagnostic systems and recognised as archaic should be removed from the psychiatric lexicon. In particular, we are talking about symptoms such as emasculation of emotions, pretentiousness, paradoxicality, eccentricity, ambivalence.

Neurology Bulletin. 2023;LV(2):5-11
pages 5-11 views

Original study arcticles

Clinical and social aspects of the quality of life in patients with Parkinson’s disease
Kopylova L.I., Tappakhov A.A., Nikolaeva T.Y., Popova T.E.

Parkinson’s disease (PD) is an age-related neurodegenerative disease associated with the loss of dopamine-producing neurons in the substantia nigra. The disease is manifested by motor disorders and a variety of non-motor symptoms (NMS). NMS may reduce the quality of life (QoL) of people with Parkinson’s disease (PD) more than motor manifestations, but their ultimate contribution has not been fully established.

AIM. To determine the impact of motor, cognitive and affective disorders and social factors on the quality of life of patients with PD in the Republic of Sakha (Yakutia).

MATERIAL AND METHODS. The study included 35 patients with PD, Hoehn–Yahr stage 1–3 (60% women and 40% men), mean age 64.4±2.0 years. We used scales: UPDRS, MoCA, HADS, NMSQuest, Epward Sleepiness Scale, PDQ39. The analysis of clinical signs and social factors in the studied group of patients was carried out.

RESULTS. The decrease in QoL was moderately associated with disease stage (r=0.56, p=0.009), the severity of motor manifestations (r=0.65, p <0.001) and the total number of NMS (r=0.46, p=0.008). Age and disease duration did not affect on QoL. The decrease in QoL was influenced by the presence of depression (r=0.83, p <0.001), anxiety (r=0.69, p <0.001) and cognitive decline (r=–0.46, p=0.008). Low levels of QoL were found in individual PD patients and in people with disabilities. QoL was not influenced by ethnicity, gender, employment or education. Three groups of patients with PD were identified: those with mild, moderate and severe decrease in QoL. Their clinical and social portraits are presented.

CONCLUSION. The dependence of the quality of life of patients with PD on the form of the disease, the stage of the disease, the severity of depression, social factors has been demonstrated, which requires attention not only from neurologists, but also from psychotherapists and social workers.

Neurology Bulletin. 2023;LV(2):12-19
pages 12-19 views
Probability of change in diagnosis among adult patients diagnosed with childhood mental disorders
Gazizullin T.R., Mendelevich V.D.

BACKGROUND. The problem of changing a psychiatric diagnosis is a reality.

AIM. To study the frequency and probability of changing the exposed patient at the age of psychiatric illness when moving under the supervision of a psychiatrist served by a large population.

MATERIAL AND METHODS. We analyzed 246 cases of patients who first applied to a psychiatrist in childhood (adolescence), then taken for consultative or dispensary registration. The study was follow-up in nature, was carried out with the help of the analysis of electronic databases of the RCPB. acad. V.M. Bekhterev of the Ministry of Health of the Republic of Tatarstan (Kazan), as well as by studying primary medical documentation (outpatient cards and case histories). The results of the study were processed on the basis of Statistica 6.0 and MS Excel 2020.

RESULTS. The main variants of the outcomes of mental disorders diagnosed in childhood of patients are described. It is shown that in more than half of clinical cases the confirmation of a psychiatric diagnosis at an early age is not final, and the issue of further diagnostic search remains unresolved and requires revision. Using the methods of multifactorial statistics, the main transnosological (dimensional) models of algorithms for the development of mental disorders are modeled.

Neurology Bulletin. 2023;LV(2):20-30
pages 20-30 views
Longitudinal study of coping strategies in first-time stroke patients: association with cognitive dysfunction, stroke site and depression
Savina M.A., Petrova E.A., Koltsova E.A.

BACKGROUND. Inadequate coping strategies are associated with affective disorders and poor quality of life in stroke survivors. Although coping strategies are determined by several non-modifiable factors they have been shown to change over time.

AIM. Longitudinal assessment of coping strategies and associated factors in patients with first-ever stroke.

MATERIAL AND METHODS. This study was a part of prospective observational study of a cohort of patients with first-ever stroke. Patients underwent standard psychiatric, neurological and cognitive assessment and CT. Patients without aphasia, severe fatigue, eye problems fulfilled the coping strategies indicator (Amirkhan J.H., 1990): 87 patients in the first week after stroke, 45 patients in the second week, 20 patients in 3 months, 21 patients in 6 months, 33 patients in 1 year after stroke. Non-parametric statistics were used.

RESULTS. Different coping strategies were not determined by age, gender and severity of neurological deficit; there were some correlations with educational level, work status, cognitive dysfunction, stroke volume and lesion location. There were differences in the use of coping strategies in the groups with different depression manifestations: in the group with depression manifestations in the early recovery period and later, coping strategies did not differ from the control group in the acute stroke period, but since the manifestation of depression the amount of avoidance strategies increased. In the group with pre-stroke depression, a significant increase in avoidance strategies was observed in the first week after the stroke.

CONCLUSIONS. The longitudinal study of coping strategies revealed that the use of coping strategies is a dynamic process determined by several modifiable and non-modifiable factors in combination. Coping strategies were not predictors of depression; on the contrary, depression seems to influence the choice of coping strategies.

Neurology Bulletin. 2023;LV(2):31-41
pages 31-41 views
Satisfaction with life as a compliance factor of patients with schizophrenia
Ruzhenkova V.V., Khamskaya I.S., Retyunskiy K.Y., Boeva A.V., Zhigulina O.V.

BACKGROUND. One of the main problems of patients in a psychiatric clinic is non-compliance with the order of treatment, which leads to frequent exacerbations of the disease and social exclusion. According to some reports, about 30–50% of patients completely refuse treatment after hospitalization or take medications in reduced doses. Important among the factors affecting the compliance of patients with schizophrenia are the patient’s personal characteristics, the severity of symptoms, criticism of the disease, substance abuse, side effects of drugs, features of therapeutic cooperation and other factors.

AIM was to analyse the relationship between life satisfaction and compliance in patients with schizophrenia.

MATERIAL AND METHODS. We examined 157 patients diagnosed with Schizophrenia aged 23 to 52 years (38.5±8.1 years). The examination was carried out one week before discharge from the hospital. The main methods of the study were clinical-psychopathological, clinical-dynamic, psychometric (DAI-10 compliance scale, Q-LES-Q-SF test for assessing the degree of satisfaction with life, Beck hopelessness scale, hospital anxiety and depression scale — HADS), and statistical (descriptive statistics, χ2 test with Yates correction for contingency tables 2×2, correlation analysis — Spearman’s rank correlation coefficient).

RESULTS. It was found that only 11.4% of males and 20.7% of females were fully compliant. A third of the men and half of the women took medication under the supervision of relatives. Only 12.6% of patients with schizophrenia were satisfied with their lives (without gender differences). A significant proportion of patients (43.3%) experienced a feeling of dissatisfaction with life, and males are 2 times more likely than women. Also, some patients at the time of discharge overestimated their mood, which did not correspond to the subjective assessment. Severe depression, anxiety and a sense of hopelessness increased the patients’ dissatisfaction with all parameters of everyday life. Compliance of patients directly depends on their mood, ability to work, perform everyday household duties and relationships with others, which becomes problematic with anxiety, depression and a sense of hopelessness.

CONCLUSION. Compliance is directly correlated with the quality of life, satisfaction with it, the physical condition of the patient, favourable family relationships, good mood, availability and job satisfaction.

Neurology Bulletin. 2023;LV(2):42-51
pages 42-51 views


The prevalence of mental disorders in patients with posterior segment eye disease
Jakovlev D.A., Shurygina A.D., Kuzmina S.V., Rascheskov A.Y.

The article presents materials from foreign and domestic literature, that indicate the relationship between ophthalmic pathology and mental disorders. The most common mental disorders are depression and anxiety among patients with visual impairment. The prevalence of comorbidity of ophthalmic and mental pathology was considered, as well as factors contributing to the progression of these diseases.

Neurology Bulletin. 2023;LV(2):52-61
pages 52-61 views

Case reports

Challenges in diagnosing personality disorders: transitioning from categories to dimensions. Clinical case.
Katok A.A., Beybalaeva T.Z.

This article discusses the features of categorical and dimensional approaches to diagnosing personality disorders. The application of the ICD-10 and ICD-11 classifications is demonstrated using a clinical case of a patient with a personality disorder with mixed dissociative symptoms. The advantages and disadvantages of both approaches are considered, as well as the need to implement validated tools for assessing the severity of personality disorders in clinical practice.

Neurology Bulletin. 2023;LV(2):62-70
pages 62-70 views

Clinical Practice Guidelines

Anorexia nervosa and bulimia nervosa: are these diseases really antipodes?
Sivolap Y.P., Portnova A.A.

Anorexia nervosa and bulimia nervosa are the main forms of eating disorders that characterized by both obvious similarities and certain differences between each other. The commonality of the two disorders is determined by the predominant occurrence in adolescent and young women, deterioration of physical health, significant psychiatric comorbidity and high suicidal risk. Psychotherapy is the principal treatment for both anorexia nervosa and bulimia nervosa. At the same time, unlike anorexia nervosa, the pharmacological agents with proven clinical efficacy for the treatment of bulimia nervosa exist. Patients with bulimia nervosa are more motivated and adherent to treatment.

Neurology Bulletin. 2023;LV(2):71-80
pages 71-80 views


How misunderstanding the principles and limitations of evidence-based medicine may discredit the concept
Zorin N.A.

The discussion on the methodological limitations of the quasi- measurement of human feelings and sensations, started by the author in the journal Neurology bulletin, continues. There are a number of reasons for accepting/rejecting and understanding the principles and limitations of clinical epidemiology/evidence-based medicine (EBM) to the point of deliberate distortion. It is shown that the ideas of “freedom” and “creativity” in medicine, are ways of avoiding control and the realization of biopower. A concrete example, the study of the efficacy of antidepressants, shows how it is possible, either unintentionally or intentionally, to obtain a false result without following the principles and tenets of EBM.

Neurology Bulletin. 2023;LV(2):81-89
pages 81-89 views

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